Welcome! My name is Alper Karagöl (he/him).
I am a researcher in evolutionary structural biology. It is an area of biological structures (i.e Proteins, Lipids, DNA), focusing on how they evolved, and how they found their roles in disease presentations. Based in Istanbul and London, my research focuses on the evolution of neurotransmitter transporters, membrane receptors and beyond.
I currently work as an intern Doctor med. (pre-registered physician) at Istanbul University Hospital. I conduct structural research with Shuguang Zhang at MIT and participate a genomic research collab with Darwin Building UCL (Steven J Perkins).
Research Areas:
Protein-Protein Interactions and Self-Assembly
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Neuronal proteins, their oligomers and dimers
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Inhibitory truncated isoforms of transporters and membrane proteins
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Isoform-based Tau-like self-assemblies
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Water-soluble QTY-variants of membrane proteins, neuronal proteins
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MD simulations for membrane proteins, lipid distortions
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MMGBSA, MMPBSA, and SVM predictions of binding affinity
Karagöl et al. 2024b Pharm Res
Computational Evolutionary Biology
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Evolutionary residue analysis
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Partial Spearman correlations and statistical modeling
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Kernel causality and confounding variable partial correlations
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Puryfiying selection, Shannon entropy, and evolutionary models
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Genetic code structure and mutational pathways (e.g., V>A>T mutations)
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Evolutionary Game Theory
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Modeling evolutionary nodes in R
Karagöl A & Karagöl T. 2024 bioarxiv
Recent Updates:
Super excited to share our research paper on the inhibition of glutamate transporter oligomerization! 🎉